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butabarbital will reduce the extent or outcome of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Result of coadministering a robust CYP3A4 inducer with fedratinib has not been studied.butabarbital will lower the extent or result of fosphenytoin by influencing hepatic enzyme CYP2C9/10 metabolism.